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Enzo Life Sciences Mirin (25mg). CAS: 299953-00-7
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Supplier:  Enzo Life Sciences BMLGR3570025

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The MRN-ATM pathway is essential for sensing the signaling from DNA double-strand breaks. Mirin is an inhibitor of MRN discovered using a forward chemical genetic screen. It prevents MRN-dependent activation of ATM without affecting ATM protein kinase activity and it inhibits Mre11-associated exonuclease activity. IC50=66μM. It abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Alternative name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one. Purity: ≥95% (TLC). Solubility: Soluble in DMSO (25mg/ml) or DMF (25mg/ml). Long Term Storage: -20°C.

Catalog No. 50-201-1005


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