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Medchemexpress LLC Mirodenafil | 862189-95-5 | 99.9% | 531.67 | 100 MG
Supplier: Medchemexpress LLC HY14930100MG
Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. It also acts as a glucocorticoid receptor (GR) modulator and activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil is used in research for erectile dysfunction (ED), Alzheimer's disease (AD), and systemic sclerosis (SSc).
- Orally active
- Potent, reversible, and selective PDE5 inhibitor
- Glucocorticoid receptor (GR) modulator
- Activates Wnt/β-catenin signaling pathway by downregulating Dkk1 expression
- Enhances neuronal survival by protecting mitochondrial membrane potential and inhibiting apoptosis
- Inhibits GSK-3β signaling, reducing tau phosphorylation and Aβ production
- Enhances cognitive-behavioral performance in transgenic AD mice
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