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Medchemexpress LLC Mirodenafil dihydrochloride | 862189-96-6 | 99.1% | 604.59 | 100 MG
Supplier: Medchemexpress LLC HY14930A100MG
Mirodenafil dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. It also acts as a glucocorticoid receptor (GR) modulator and activates the Wnt/β-catenin signaling pathway. This compound is used in research for erectile dysfunction (ED), Alzheimer's disease (AD), and systemic sclerosis (SSc).
- Exerts neuroprotective functions by activating the cGMP/PKG/CREB signaling pathway.
- Enhances neuronal survival by protecting mitochondrial membrane potential and inhibiting apoptosis.
- Inhibits GSK-3β signaling, reducing tau phosphorylation and amyloid beta production.
- Inhibits transcriptional activity and homodimerization of the glucocorticoid receptor (GR).
- Ameliorates dermal fibrosis in an SSc mouse model by inhibiting the TGF-β signaling pathway.
- Improves cognitive-behavioral performance in transgenic AD mice.
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