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Medchemexpress LLC Mitotane | 53-19-0 | 320.04 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1369010MM/1ML

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Mitotane (2,4′-DDD) is an isomer of DDD and a derivative of dichlorodiphenyltrichloroethane (DDT). It acts as an antineoplastic agent primarily used in adrenocortical carcinoma research. Its adrenocorticolytic effect is exerted, in part, through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can also influence corticotroph cells in the pituitary and activate CYP3A4 gene expression via steroid and xenobiotic receptor (SXR).

  • Used as an antineoplastic agent in adrenocortical carcinoma research
  • Exerts adrenocorticolytic effect through lipotoxicity
  • Induces CYP3A4 gene expression via SXR activation
  • Can have direct pituitary effects on corticotroph cells

Catalog No. 50-003-48406


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