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Medchemexpress LLC Mitotane | 53-19-0 | 99.9% | 320.04 | 500 MG
Supplier: Medchemexpress LLC HY13690500MG
Mitotane (2,4'-DDD) is an antineoplastic agent used to research adrenocortical carcinoma. This isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT) primarily exerts its adrenocorticolytic effect through lipotoxicity induced by intracellular free cholesterol accumulation. It also has direct pituitary effects on corticotroph cells and can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation.
- Antineoplastic agent for adrenocortical carcinoma research.
- Exerts adrenocorticolytic effect via lipotoxicity.
- Direct pituitary effects on corticotroph cells.
- Induces CYP3A4 gene expression.
- Reduces H295R cell proliferation.
- Reduces TαT1 cell viability.
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