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Apexbio Technology LLC MK-0752(Synonyms: MK0752, MK 0752, MK-752, MK752, Gamma-secretase inhibitor MK-0752), 5mg, CAS: 471905-41-6.
Supplier: Apexbio Technology LLC A40065
MK-0752 (CAS 471905-41-6) is a small molecule inhibitor of -secretase an enzymatic complex responsible for proteolytic cleavage of the Notch receptor -secretase-mediated cleavage releases the Notch intracellular domain (NICD) thereby activating gene transcription essential for cellular differentiation proliferation and survival MK-0752 potently inhibits -secretase enzymatic activity with an IC50 of approximately 50 nM In vitro inhibition of -secretase by MK-0752 suppresses proliferation of breast cancer cells This compound has been investigated in clinical studies for advanced breast cancer and other solid tumors as well as pediatric refractory CNS malignancies underscoring its relevance for oncology research targeting Notch signaling
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