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Apexbio Technology LLC MK 886 118414-82-7 5mg
Supplier: Apexbio Technology LLC B66845
MK 886 (CAS 118414-82-7) is a small-molecule inhibitor targeting 5-lipoxygenase-activating protein (FLAP) a protein essential for activating 5-lipoxygenase and initiating leukotriene biosynthesis It is designed to block FLAP function thereby inhibiting leukotriene production derived from arachidonic acid metabolism MK 886 exerts its biological activity primarily through non-competitive antagonism of FLAP to suppress 5-LO-mediated signaling In cell-based assays using whole leukocytes and human whole blood MK 886 demonstrates inhibitory activity with IC50 values of 3 nM and 1 1 M respectively Based on these pharmacological properties MK 886 holds research potential in studies on inflammatory signaling pathways leukotriene biology and disorders such as asthma arthritis and psoriasis
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