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Apexbio Technology LLC ML-265 1221186-53-3 25mg
Supplier: Apexbio Technology LLC C418125
ML-265 (CAS 1221186-53-3) is a potent and selective small-molecule activator of pyruvate kinase M2 (PKM2) PKM2 regulates the final step of glycolysis and is predominantly expressed in highly proliferative cells including cancer cells ML-265 activates PKM2 with an AC50 of 92 nM demonstrating high selectivity over other pyruvate kinase isoforms It enhances PKM2 activity by promoting tetramer formation and lowers the enzyme s Km for phosphoenolpyruvate similar to the effect of fructose-1 6-bisphosphate In mouse xenograft models ML-265 shows favorable pharmacokinetics and suppresses tumor growth supporting its utility in studies of cancer metabolism and tumorigenesis
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