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Medchemexpress LLC ML 297 (VU 0456810) | 1443246-62-5 | 99.1% | 328.32 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY11019250MG

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ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. It has the ability to cross the blood-brain barrier in a mice model, with a brain-to-plasma ratio of 0.2. This compound shows potential for the treatment of epilepsy. The product is intended for research use only and is not sold to patients.

  • Potent and selective GIRK1/2 activator with an EC50 of 0.16 μM.
  • Can cross the blood-brain barrier in mice models.
  • Potential for the treatment of epilepsy.
  • Completely inactive for GIRK2/3.
  • Shows concentration-dependent efficacy in expressing GIRK1/2 cells.
  • Demonstrates a highly significant ability to prevent convulsions and fatality in pentylenetetrazol (PTZ)-treated mice.

Catalog No. 50-003-44861


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