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Apexbio Technology LLC ML-7 hydrochloride 110448-33-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A36265.1
ML-7 hydrochloride (CAS 110448-33-4) is a potent inhibitor of myosin light chain kinase (MLCK) with a reported Ki of 300 nM By inhibiting MLCK ML-7 modulates the phosphorylation state of myosin light chains a process implicated in the pathogenesis of cardiovascular disorders and ischemia/reperfusion (I/R) injury In vitro ML-7 suppresses neuregulin-1-induced sarcomere formation in cultured neonatal rat cardiomyocytes In vivo administration of ML-7 during I/R protocols in rat models significantly improves cardiac contractility and alters the expression of proteins involved in energy metabolism and cytoskeletal organization ML-7 is widely utilized as a research tool to dissect MLCK-dependent signaling pathways in cardiovascular and cellular physiology
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