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Medchemexpress LLC ML-7 hydrochloride | 110448-33-4 | C15H18ClIN2O2S | 25 MG
Supplier: Medchemexpress LLC 25MGHY15417
ML-7 hydrochloride is a naphthalene sulphonamide derivative that potently inhibits Myosin Light Chain Kinase (MLCK) with an IC₅₀ of 300 nM, and also inhibits YAP/TAZ. This product is intended for research use only.
- Potently inhibits Myosin Light Chain Kinase (MLCK) with an IC₅₀ of 300 nM.
- Inhibits YAP/TAZ.
- Inhibits rabbit portal vein α1-adrenoceptor NSCC with an IC₅₀ of 0.8 μM.
- Attenuates Dexmedetomidine (DMT)-induced contraction.
- Reduces intracerebral Evans Blue extravasation, suggesting a reduction in brain edema.
- Reduces brain water content and improves neurological function after controlled cortical impact (CCI).
- Significantly reduces the protein level of phosphorylated MLC2 and the phosphorylation ratio of MLC2 in BMECs.
- Directly inhibits the expression of ZO-1.
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