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Medchemexpress LLC ML228 | 1357171-62-0 | 98.0% | 10 MG
Supplier: Medchemexpress LLC HY1275410MG
ML228 is a potent Hypoxia Inducible Factor (HIF) pathway activator with an EC50 of 1 μM. It potently activates HIF in vitro as well as its downstream target VEGF. ML228 represents a novel chemotype for the study of HIF activation and its therapeutic potential.
- Potently activates HIF in vitro
- Activates downstream target VEGF
- Novel chemotype for HIF activation studies
- Structurally different from known HIF activators
- Lacks acidic functional group found in PHD inhibitors
- Improves local hypoxic ischemia environment in vivo
- Reduces SCI secondary injury in vivo
- Promotes recovery of neurological function in SD rats
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