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Apexbio Technology LLC ML241 hydrochloride 2070015-13-1 10mg
Supplier: Apexbio Technology LLC B612210
ML241 hydrochloride (CAS 2070015-13-1) is a selective inhibitor of the p97 ATPase a conserved hexameric member of the type II AAA ATPase protein family essential to eukaryotic cellular processes including cell division membrane fusion and autophagosome maturation ML241 exhibits an in vitro IC50 of 100 nM against p97 It impedes p97-dependent but not p97-independent proteasomal substrate degradation and disrupts endoplasmic reticulum-associated degradation pathways Compared to the related compound ML240 ML241 does not induce LC3-II accumulation or rapid activation of caspases in cancer cells ML241 has minimal off-target activity toward kinases and CNS-related proteins and is currently used in preclinical studies to elucidate p97 function and proteostasis mechanisms
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