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Medchemexpress LLC ML351 | 847163-28-4 | 99.2% | 249.27 | 10 MG
Supplier: Medchemexpress LLC HY11131010MG
ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. It demonstrates excellent selectivity (>250-fold) over related isozymes such as 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. ML351 has been shown to prevent dysglycemia and reduce β-cell oxidative stress in a nonobese diabetic mouse model of T1D.
- Potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM.
- Exhibits excellent selectivity (>250-fold) against related isozymes, including 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2.
- Prevents dysglycemia and reduces β-cell oxidative stress in a nonobese diabetic mouse model of T1D.
- Protects against diabetes development in an STZ β-cell injury model.
- Leads to improved glycemic control and significantly reduced insulitis in NOD mice.
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