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Medchemexpress LLC ML382 | 1646499-97-9 | 99.9% | 360.43 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY110285100MG

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ML382 is a potent and selective positive allosteric modulator of MRGPRX1 (Mas-related G protein-coupled receptor X1, MrgX1), with an EC50 of 190 nM.

  • Increases the potency of BAM8-22, demonstrating positive allosteric modulator activity on MRGPRX1.
  • In *in vitro* studies, significantly increases the inhibition of ICa by a low concentration of BAM8-22 in DRG neurons from MrgprX1 mice.
  • Enhances the inhibition of spinal synaptic transmission by BAM8-22 in MrgprX1 mice.
  • Dose-dependently attenuates heat hypersensitivity in MrgprX1 mice.
  • A lumbar puncture injection leads to a significant increase in postconditioning time spent in the ML382-paired chamber.
  • Inhibits nerve injury-induced ongoing pain in MrgprX1 mice.

Catalog No. 50-003-43611


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