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Abcam MLN-4924, NEDD8-activating enzyme inhibitor, 1MG

Supplier:  Abcam AB2164701MG

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MW 443.5 Da, Purity >98%. Potent NEDD8-activating enzyme (NAE) inhibitor (IC₅₀ = 4.7 nM). Selective relative to the closely related activating enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE). Adenosine 5'-monophosphate analog. Disrupts cullin-RING ligase (CRL)-mediated protein turnover leading to apoptosis in human tumour cells by deregulating S-phase DNA synthesis.

The product is subject to the following: Abcam Restricted Use Statement

Catalog No. 50-270-4314


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