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Medchemexpress LLC MMG-11 | 313254-94-3 | 306.27 | 100 MG
Supplier: Medchemexpress LLC HY112146100MG
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. It inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses.
- Potent and selective human TLR2 antagonist.
- Low cytotoxicity.
- Inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses.
- Does not show cellular toxicity or interference with signaling induced by other TLR agonists, IL-1β or TNF.
- Exhibits no cytotoxic effects up to 100 μM in peripheral blood mononuclear cells (PBMCs).
- Effective inhibition of TLR2/1 and TLR2/6 signaling.
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