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Apexbio Technology LLC MN 64 92831-11-3 100mg
Supplier: Apexbio Technology LLC B5983100
MN 64 (CAS 92831-11-3) is a flavone-based small molecule that functions as a potent and selective inhibitor of tankyrase enzymes TNKS1 and TNKS2 with IC50 values of 6 nM and 72 nM respectively Tankyrases are poly(ADP-ribose) polymerases involved in processes such as regulation of cell proliferation and telomere maintenance In cellular assays MN 64 effectively suppressed STF luciferase activity at 200 nM and demonstrated high selectivity for tankyrase isoforms over other PARPs Due to its potency and selectivity MN 64 serves as a valuable chemical probe for studying tankyrase-mediated cellular pathways and evaluating therapeutic potential in related research contexts
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