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Medchemexpress LLC Monomethyl auristatin E | 474645-27-7 | MFCD09935109 | C68H105N9O15 | 100 MG
Supplier: Medchemexpress LLC HY15162G100MG
Monomethyl auristatin E (MMAE) (GMP) is a tubulin polymerization inhibitor produced using GMP guidelines.
- Produced using GMP guidelines
- Tubulin polymerization inhibitor
- Efficiently released from SGN-35 within CD30+ cancer cells
- Able to exert cytotoxic activity on bystander cells due to membrane permeability
- Sensitizes colorectal and pancreatic cancer cells to IR in a schedule and dose-dependent manner correlating with mitotic arrest
- Radiosensitization evidenced by decreased clonogenic survival and increased DNA double-strand breaks in irradiated cells
- In combination with IR, results in tumor growth delay
- Tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolongs tumor regression in xenograft models
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