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Cayman Chemical mP-2mP-9 InhIbItr IIItr 1mg
Supplier: Cayman Chemical 246971 MG
An inhibitor of MMP-2 and MMP-9 (IC50s = 10-20 μM, for both); selective for MMP-2 and MMP-9 over MT1-MMP, MMP-8, and MMP-13 as well as the serine proteases trypsin-2, neutrophil elastase, and cathepsin G (500 μM); reduces migration of HT1080 fibrosarcoma, C8161 melanoma, SKOV3 ovarian carcinoma, and KS1767 Kaposi's sarcoma cells in vitro; pretreatment delays tumor formation in an MDA-MB-435 mouse xenograft model; prevents growth of established tumors in MDA-MB-435 and KS1767 mouse xenograft models
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