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Medchemexpress LLC MRGPRX1 agonist 1 | 2377379-39-8 | 99.95% | 1 ML
Supplier: Medchemexpress LLC HY13011810MM/1ML
MRGPRX1 agonist 1 is a highly potent and selective agonist for MRGPRX1, with an EC50 of 50 nM. It exhibits over 50-fold selectivity compared to δ, μ, and κ opioid receptors and is inactive against MRGPRC11. This compound is valuable for studying chronic pain, particularly neuropathic pain.
- Highly potent MRGPRX1 agonist
- Greater than 50-fold selectivity for δ, μ, and κ opioid receptors
- Inactive against MRGPRC11
- Useful for the study of chronic pain
- EC50 of 50 nM for MRGPRX1
- Inhibits high voltage-activated (HVA) Ca2+ currents
- Reduces neurotransmitter release
- Mitigates nociceptive transmission in the spinal cord
- Shows good distribution to the spinal cord in male mice
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