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Medchemexpress LLC MS023 | 1831110-54-3 | 99.9% | 287.40 | 100 MG
Supplier: Medchemexpress LLC HY19615100MG
MS023 is a chemical probe and a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs), with IC50s of 30, 119, 83, 4, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8. It is utilized for research in epigenetics, particularly in studies involving histone methyltransferases, and demonstrates antiproliferative effects against human A549, HCC4006, and SK-LU-1 cells.
- Potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs)
- Inhibits PRMT1 methyltransferase activity in MCF7 cells
- Inhibits PRMT6 methyltransferase activity in HEK293 cells
- Blocks MLL-r acute lymphoblastic leukemia (ALL) propagation in animal models
- Extends survival of leukemic mice in combination treatments
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