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Cayman Chemical MS023hydrochlorIde 10mg
Supplier: Cayman Chemical 1836110 MG
An inhibitor of type I PRMTs (IC50s = 30, 119, 83, 4, and 5 nM for PRMT1, -3, -4, -6, and -8, respectively); selective for these type I PRMTs over PRMT5, -7, and -9, as well as a panel of 25 PKMTs and DNMTs at 10 µM; inhibits methylation of H4R3 in MCF-7 cells and H3R2 in HEK293 cells (IC50s = 9 and 56 nM, respectively); inhibits methylation of the SARS-CoV-2 nucleocapsid protein and the replication of SARS-CoV-2 in Vero E6 cells at 20 µM; reduces tumor growth in a Huh7 mouse xenograft model at 160 mg/kg
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