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Medchemexpress LLC MS1943 | 2225938-17-8 | 98.9% | C42H54N8O3 | 10MG
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Supplier:  Medchemexpress LLC HY13312910MG

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MS1943 is an orally active, PROTAC-based selective degrader of EZH2 that reduces EZH2 protein levels and shows anticancer activity in preclinical cellular and xenograft models.

  • PROTAC-based mechanism targeting EZH2 methyltransferase.
  • Potent biochemical activity: IC50 120 nM for EZH2.
  • Cellular activity: inhibits cell growth (GI50 2.2 μM in MDA-MB-468) and induces apoptosis in cancer models.
  • High chemical purity (reported 98.92%).
  • Physical form: light yellow to yellow solid.
  • Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).
  • Molecular formula C42H54N8O3; molecular weight 718.93.

Catalog No. 50-002-61711


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