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Medchemexpress LLC MS8511 hydrochloride | 3031788-28-7 | C28H42ClN5O3 | 5 MG
Supplier: Medchemexpress LLC HY150510A5MG
MS8511 hydrochloride is an off-white to light yellow solid. It is a specific, covalent, and irreversible inhibitor of G9a/GLP, targeting the cysteine residue at the substrate binding site.
- Specific covalent and irreversible inhibitor of G9a/GLP
- Targets the cysteine residue at the substrate binding site
- IC50 of 100 nM for G9a and 140 nM for GLP
- Kd values of 44 nM for G9a and 46 nM for GLP
- Reduces intracellular H3K9me2 levels
- Enhances antiproliferative activity
- Useful for studying various cancers and other diseases like Alzheimer's disease, sickle cell disease, and Prader-Willi syndrome
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