Medchemexpress LLC MSN-50 | 2165322-94-9 | MFCD32201047 | ≥98.0% | 422.21 g/mol | C17H16BrF4NO2 | 1 ML

Supplier:  Medchemexpress LLC HY11737010MM 1ML

USP25/28 inhibitor AZ1 is a selective, noncompetitive dual inhibitor of the deubiquitinases USP25 and USP28. Provided as a 10 mM solution in DMSO (1 mL), it exhibits potent biochemical activity and has demonstrated efficacy in cellular and mouse models of colitis and colon tumorigenesis.

• Selective, noncompetitive dual inhibitor of USP25 and USP28.
• Potent biochemical activity (IC50 ≈ 0.7 μM for USP25; ≈ 0.6 μM for USP28).
• Supplied as a 10 mM solution in DMSO for convenient in vitro dosing.
• Documented efficacy in mouse models, including attenuation of colitis and reduction of colon tumorigenesis.
• Suitable for biochemical assays, cell-based studies, and in vivo experiments with appropriate formulation.

Catalog No. 50-002-27078