Cayman Chemical Muraglitazar Other Receptor Mo

Supplier:  Cayman Chemical 100078531 MG

A dual agonist of PPARα and PPARγ (EC50s = 0.32 and 0.11 μM, respectively); selective for PPARα/γ over other nuclear receptors, including PPARδ, RXRα, RARs, ERα/β, AR, and PR; reduces the size of lipid droplets in oleic acid-treated HepaRG human hepatocytes at 50 μM; reduces plasma levels of glucose, triglycerides, free fatty acids, and insulin by 54, 33, 62, and 48%, respectively, in db/db mice at 10 mg/kg per day; reduces plasma levels of glucose, triglycerides, and cholesterol in diet-induced obese mice at 10 mg/kg per day; inhibits LPS-induced increases in NO production and IL-6, TNF-α, and iNOS protein levels in J774 murine macrophages; inhibits carrageenan-induced paw edema in mice at 12.5-50 mg/kg

Catalog No. 50-288-9141