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Medchemexpress LLC MYF-01-37 | 2416417-65-5 | 99.44% | 298.30 | 1 ML
Supplier: Medchemexpress LLC HY13960310MM/1ML
MYF-01-37 is a covalent TEAD inhibitor that targets Cys380 and exhibits reversible inhibition on YAP/TEAD interaction. It is intended for research use only. In vitro studies show it inhibits direct YAP/TEAD interaction in HEK 293T cells and reduces canonical YAP target gene CTGF expression in PC-9 cells, with minimal impact on cell viability in several EGFR-mutant NCSLC cell lines.
- Covalent TEAD inhibitor
- Targets Cys380
- Reversibly inhibits YAP/TEAD interaction
- Minimally impacts cell viability in EGFR-mutant NCSLC cell lines
- Decreases dormant cells when combined with OT (osimertinib and trametinib)
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