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Apexbio Technology LLC Myriocin(Synonyms: ISP-1, Thermozymocidin, Antibiotic ISP-1, Mycelia Sterilia metabolite), 25mg, CAS: 35891-70-4.
Supplier: Apexbio Technology LLC B606425
Myriocin (CAS 35891-70-4) is a selective inhibitor of serine palmitoyltransferase (SPT) an enzyme catalyzing the initial step in de novo sphingolipid biosynthesis By inhibiting this pathway (Ki 0 28 nM) myriocin exerts immunosuppressive and antiproliferative effects In vitro studies show dose-dependent inhibition of cell growth in A549 (IC50 30 M) and NCI-H460 (IC50 26 M) lung cancer cell lines In vivo myriocin suppresses tumor formation in murine melanoma models and influences expression of cell cycle regulators (Cdc25C Cdc2 cyclin B1) and tumor suppressor pathways (p53 p21) Myriocin is thus utilized in research exploring sphingolipid metabolism oncology and immunology
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