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Medchemexpress LLC N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine | 82964-04-3 | 99.4% | 357.35 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY16500100MG

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Tolrestat is a potent, orally active aldose reductase inhibitor with an IC50 of 35 nM. It has been shown to reverse elevated red blood cell sorbitol levels in diabetic rats. Studies in diabetic rats have also indicated its inhibitory effect on tissue aldose reductase activity in the sciatic nerve and lenses. Tolrestat does not significantly affect plasma lipoprotein levels, body weight, or general health in mice.

  • Potent and orally active aldose reductase inhibitor.
  • Exhibits an IC50 of 35 nM.
  • Reverses high red blood cell sorbitol levels in diabetic rats.
  • Inhibits aldose reductase activity in sciatic nerve and lenses.
  • Does not significantly impact plasma lipoprotein levels.

Catalog No. 50-003-94210


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