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Medchemexpress LLC N-cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine | 1125758-85-1 | ≥98.0% | 315.37 | C19H17N5 | 1 MG
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Supplier:  Medchemexpress LLC HY1004831MG

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A-804598 is a CNS-penetrant, competitive, and selective antagonist of the P2X7 purinergic receptor used to block P2X7-mediated signaling and inflammasome-related responses. It exhibits low-nanomolar potency at mammalian P2X7 receptors (mouse ≈9 nM, rat ≈10 nM, human ≈11 nM) and has been used as a high-affinity radioligand in receptor binding studies.

  • CNS-penetrant antagonist suitable for in vitro and in vivo studies.
  • Low-nanomolar potency across mouse, rat, and human P2X7 receptors.
  • Competitive and selective profile for P2X7 over other purinergic receptors.
  • Blocks IL-1β release and Yo-Pro uptake in cellular assays.
  • Typically supplied at high purity for pharmacological applications.

Catalog No. 50-002-14744


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