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Medchemexpress LLC N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[(2-(trifluoromethyl)phenyl)methyl]piperidine-4-carboxamide | 1627138-52-6 | 99.9% | 494.53 g/mol | C23H25F3N4O3S | 25MG
SDP

Supplier:  Medchemexpress LLC HY1243925MG

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ML380 is a potent, subtype-selective, brain-penetrant positive allosteric modulator (PAM) of the M5 muscarinic acetylcholine receptor intended for laboratory research use only. Reported activity includes EC50 ≈190 nM for human M5 and ≈610 nM for rat M5, with moderate selectivity over M1 and M3 subtypes. Typical supplied purity is ≈99.9% and the compound is provided in small milligram packaging for experimental studies.

  • Potent M5 mAChR positive allosteric modulator activity (EC50 ≈190 nM human).
  • Brain-penetrant profile suitable for central nervous system studies.
  • Moderate selectivity versus M1 and M3 receptor subtypes.
  • C23H25F3N4O3S, molecular weight 494.53 g/mol.
  • High purity (≈99.9%) for reproducible experimental results.
  • Available in small milligram quantities for dose-ranging experiments.

Catalog No. 50-002-36293


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