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Abcam N-Palmitoyl phosphatidylethanolamine, Endogenous lipid anorectic hormone, 5MG
Supplier: Abcam AB1452195MG
MW 930.4 g/mol, Purity >98%. Endogenous lipid which significantly reduced food intake in a dose-dependent fashion when administered to rats and mice without causing taste aversion. Found to enter the brain (concentrating in the hypothalamus) when administered systemically and also reduced food intake when infused intracerebroventricularly (nanomolar concentrations), suggesting that mediation of effects is via the CNS. Chronic infusion resulted in a reduction of both food intake and body weight, suggesting that NAPE and long-acting NAPE analogs may be novel therapeutic targets for the treatment of obesity.
The product is subject to the following: Abcam Restricted Use Statement
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