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Medchemexpress LLC N-Propargylglycine | 58160-95-5 | 99.7% | C5H7NO2 | 25 MG
Supplier: Medchemexpress LLC 25MGHY142035
N-Propargylglycine is a brain-penetrant, orally active PRODH inhibitor. It works by covalently modifying enzyme-bound FAD and active site lysine, leading to enzyme structural distortion, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. It can induce UPRmt, upregulate mitochondrial chaperones, and enhance mitochondrial proteostasis.
- Brain-penetrant and orally active.
- Irreversibly inhibits proline oxidation.
- Induces mitochondrial unfolded protein response.
- Blocks astrocytic L-proline consumption.
- Stimulates neural processes and increases brain amino acid levels.
- Reduces hyperoxaluria and prevents calcium oxalate stone formation.
- Used in research for breast cancer, neurodegenerative disorders, and primary hyperoxaluria.
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