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ABclonal Technology N6-methyladenosine / m6A
Supplier: ABclonal Technology A2241120UL
Discovered in the 1970s m6A is the most prevalent internal modification in polyadenylated mRNAs and long non-coding RNAs (lncRNAs) in higher eukaryotes m6A is widely conserved among eukaryotic species that range from yeast plants flies to mammals as well as among viral RNAs with a nuclear phase The m6A-based modification is associated with a well-defined RNA motif RRACH (R A G H A C U) As a representative of the epitranscriptome m6A mRNA modifications participate in many vital activities in the cell including stem cell self-renewal and differentiation mRNA transcription alternative splicing nuclear export translation degradation and microRNA processing These processes determine the expression or inactivation of specific genes which is vital for growth and development (PMID 30416848 PMID 24662220 PMID 30429466)
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