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Apexbio Technology LLC Naloxone (hydrochloride) 357-08-4 100mg
Supplier: Apexbio Technology LLC B8208100
Naloxone (hydrochloride CAS 357-08-4) is a potent opioid receptor antagonist with high affinity for - - and -opioid receptors These receptors modulated by endogenous peptides and exogenous opioids such as morphine and heroin regulate processes including nociception reward and hormone secretion In cellular models naloxone has been shown to enhance neural stem cell proliferation in a concentration-dependent manner surpassing the proliferative effect of morphine at equivalent concentrations Additionally high concentrations of naloxone markedly reduce natural killer cell activity in human peripheral blood mononuclear cells In behavioral studies with rats naloxone administration led to a dose-dependent decrease in motivation and locomotor activity related to alcohol consumption This compound is widely utilized in research involving opioid signaling pathways neurogenesis and immune modulation
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