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Medchemexpress LLC Naluzotan | 740873-06-7 | 98.05% | 450.64 | 1 MG
Supplier: Medchemexpress LLC HY148481MG
Naluzotan is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of approximately 20 nM and 5.1 nM, respectively. It is used for the treatment of anxiety and depression. It also acts as a weak hERG K+ channel blocker, with an IC50 of 3800 nM.
- Novel, potent, and selective amidosulfonamide 5-HT1A agonist
- Used for the treatment of anxiety and depression
- Acts as a weak hERG K+ channel blocker
- Exhibits full agonism in in vitro functional assays
- Shows significant affinity for the guinea pig sigma receptor
- Does not inhibit major cytochrome P450 isoforms
- Demonstrates significant brain penetration
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