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Medchemexpress LLC Naproxen etemesil | 385800-16-8 | 99.89% | 336.40 | 100 MG
Supplier: Medchemexpress LLC HY19675100MG
Naproxen etemesil is described as a lipophilic, non-acidic, and inactive proagent of naproxen. It becomes pharmacologically active Naproxen after hydrolysis and absorption. Naproxen functions as an inhibitor of both COX-1 and COX-2, with IC50 values of 8.72 μM and 5.15 μM respectively in cell assays.
- Functions as an inactive proagent that converts to active naproxen upon absorption.
- Its active form is a COX-1 and COX-2 inhibitor.
- Has demonstrated anti-inflammatory and antifibrotic effects in a mouse model of bleomycin-induced lung fibrosis.
- Downregulates TGF-β levels and Smad3/4 complex formation.
- Inhibits the time-courses of pain, fever, and PGE2.
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