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Cayman Chemical nbIvololhydrochlorIde 10mg
Supplier: Cayman Chemical 2366010 MG
A β1-AR antagonist (IC50 = 7.41 nM); selective for β1- over β2-ARs (IC50 = 251 nM), as well as 5-HT1A and 5-HT2, α1- and α2-adrenergic, histamine H1, and dopamine D2 receptors (IC50s = 27.5, 2,239, 3,162, >10,000, 5,623, and 10,000 nM, respectively); induces vasodilation in isolated mouse renal arteries (EC50 = 11.36 μM) and decreases isoproterenol-induced contraction of isolated human left ventricular trabeculae (IC50 = 7 µM); inhibits proliferation of primary HCASMCs in the presence and absence of growth factors (IC50s = 6.1, 6.8, 6.4, and 7.7 μM for HCASMCs grown in media containing no growth factor, PDGF-BB, basic FGF, and TGF-β1, respectively); an inhibitor of the SARS-CoV-2 Mpro (IC50 = 60.2 UG/ml); inhibits SARS-CoV-2 pathogenicity in vitro (IC50 = 0.03 UG/ml)
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