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ABclonal Technology NDUFS1 Rabbit mAb
Supplier: ABclonal Technology A2119220UL
The protein encoded by this gene belongs to the complex I 75 kDa subunit family Mammalian complex I is composed of 45 different subunits It locates at the mitochondrial inner membrane This protein has NADH dehydrogenase activity and oxidoreductase activity It transfers electrons from NADH to the respiratory chain The immediate electron acceptor for the enzyme is believed to be ubiquinone This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme It may form part of the active site crevice where NADH is oxidized Mutations in this gene are associated with complex I deficiency Several transcript variants encoding different isoforms have been found for this gene
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