Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC NecroIr1 | 98.0% | 823.36 g/mol | C40H29ClIrN5O | 10 MG
Supplier: Medchemexpress LLC HY14836510MG
NecroIr1 is an iridium(III) coordination complex used as a research reagent to induce necroptosis in cisplatin-resistant lung cancer cells (A549R). It preferentially accumulates in mitochondria, promotes reactive oxygen species (ROS) generation and loss of mitochondrial membrane potential, activates necroptosis-associated kinases, and induces G0/G1 cell-cycle arrest that inhibits cell proliferation in vitro.
- High purity (98.02%) suitable for cellular assays.
- Preferential mitochondrial accumulation enabling targeted ROS generation.
- Activates necroptosis signaling through RIPK1, RIPK3, and MLKL.
- Induces G0/G1 cell-cycle arrest and inhibits proliferation in resistant lung cancer cells.
- Provided as a solid 10 mg unit for laboratory studies.
- Store sealed at 4°C; in solvent: -80°C (6 months), -20°C (1 month).
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?