Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC NecroIr2 | 98.0% | 926.44 | 5 MG
Supplier: Medchemexpress LLC HY1483665MG
NecroIr2 is an iridium(III) complex that acts as a necroptosis inducer in Cisplatin-resistant lung cancer cells (A549R). It selectively accumulates in mitochondria, causing oxidative stress and a decrease in mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), and also regulates CDK4 expression.
- Induces necroptosis by activating RIPK3 and MLKL, and regulating CDK4 expression.
- Over 90% accumulates in mitochondria in A549R and CFSE labelled L02 cells.
- Leads to increased ROS generation and loss of mitochondrial membrane potential.
- Induces necroptosis by arresting the cell cycle at the G0/G1 phase in a dose-dependent manner.
- Inhibits the proliferation of A549R cells in a dose-dependent manner.
- Appears as a brown to reddish brown solid.
- Soluble in DMSO at 50 mg/mL.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?