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Cayman Chemical Necrostatin5 Inhibitors
Supplier: Cayman Chemical 1052725 MG
A RIP1 kinase inhibitor; inhibits phosphorylation of RIP1 in Jurkat cells at 10 and 30 µM; inhibits TNF-α-induced necroptosis in FADD-deficient Jurkat cells (EC50 = 0.24 µM); reduces LDH release in S. marcescens-infected MH-S macrophages; improves survival in a mouse model of S. marcescens-induced pneumonia at 100 µM, i.p.
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