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Medchemexpress LLC Neratinib | 698387-09-6 | MFCD09752958 | 99.9% | 557.0 g/mol | 1 ML
Supplier: Medchemexpress LLC HY3272110MM/1ML
Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively.
- Inhibits proliferation of cell lines with high HER-2 levels.
- Less active in cell lines not expressing HER-2 or EGFR.
- Arrests cell cycle at G1-S phase.
- Causes inhibition of MAPK and Akt phosphorylation, down-regulation of cyclin D1 levels, and induction of p27.
- Shows anticancer activities against cancer cells expressing high levels of HER-2 or EGFR in vivo.
- Reduces tumor growth in a dose-dependent manner in xenografts.
- Inhibits phosphorylation of HER-2 in xenografts.
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