Apexbio Technology LLC NF 449 627034-85-9 50mg

Supplier:  Apexbio Technology LLC B671650

NF 449 (CAS 627034-85-9) is a potent and selective antagonist of purinergic P2X1 receptors displaying an IC50 of 0 28 nM in rat models This compound inhibits ATP-induced activation of P2X1 ion channels which are significant in platelet function In vitro studies demonstrate that NF 449 efficiently blocks P2X1-mediated responses with higher selectivity compared to P2Y1 and P2Y12 receptors In vivo NF 449 selectively suppresses P2X1-mediated platelet aggregation and thrombus formation without substantially affecting bleeding time at lower doses NF 449 serves as a valuable tool for investigating P2X1 receptor function and the role of platelet P2 receptors in thrombosis

Catalog No. 50-000-91201