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Abcam NF-kappaB Activation Inhibitor VI, benzo x athiole compound, 25MG
Supplier: Abcam AB14595425MG
MW 273.4 Da, Purity >95%. Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser¹⁷⁷ and/or Ser¹⁸¹ residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation (IC₅₀ = 1.0 μM) and nitrite production (IC₅₀ = 0.7 μM) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice in vivo.
The product is subject to the following: Abcam Restricted Use Statement
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