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Apexbio Technology LLC NH125 278603-08-0 2mg
Supplier: Apexbio Technology LLC A88142
NH125 (CAS 278603-08-0) is a small-molecule inhibitor targeting eukaryotic elongation factor-2 kinase (eEF-2K) It is designed to inhibit eEF-2K activity thereby modulating protein translation via phosphorylation of eEF-2 NH125 exerts its biological activity primarily through selective inhibition of eEF-2K In cell-based studies NH125 demonstrates potent inhibition with an IC50 value of approximately 60 nM It also inhibits eEF-2 phosphorylation suppresses cell viability and induces G0-G1 arrest in cancer cell lines at submicromolar concentrations Based on these pharmacological properties NH125 holds research potential in cancer and vascular biology
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