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Medchemexpress LLC Nifuroxazide | 965-52-6 | 99.9% | 1 ML
Supplier: Medchemexpress LLC HYB143610MM/1ML
Nifuroxazide is an effective inhibitor of STAT3, also exerting potent anti-tumor and anti-metastasis activity. It is an orally active nitrofuran antibiotic.
- Target is STAT3.
- Exhibits cytotoxicity against various human and NIH3T3 cell lines.
- Induces a significant dose-dependent decrease in STAT3 tyrosine phosphorylation in U266 cells.
- Causes dose-dependent loss of cell viability in U266 and INA6 cells.
- Inhibits tumor growth and weight in a dose-dependent manner.
- Inhibits proliferation of Ki-67-positive cells and induces apoptosis.
- Inhibits expression of MMP-2, MMP-9, and p-Stat3 in tumor tissues.
- Inhibits infiltration of MDSCs into the lung, suppressing distant colonization of tumor cells.
- Appearance is solid.
- Color is light yellow to yellow.
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