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Apexbio Technology LLC Nisin 1414-45-5 10g
Supplier: Apexbio Technology LLC C353110000
Nisin a member of lantibiotic antibiotics is an antibacterial peptide synthesized by Lactococcus lactis utilizing uncommon amino acids such as lanthionine This compound has demonstrated antimicrobial activity through pore formation in bacterial cell membranes In vitro research indicates that nisin could inhibit mammalian sperm motility rapidly at concentrations ranging from approximately 50 g (rat) to 300-400 g (human and non-human primate) displaying dose- and time-dependent inhibition In animal studies intravaginal application before mating terminated sperm motility and prevented fertilization without observable toxicity Current investigations explore nisin as a potential topical contraceptive agent yet clinical trials have not commenced and an explicit IC50 value remains unreported
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