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Cayman Chemical NIsoxetInhydrochlorIde 10mg
Supplier: Cayman Chemical 2963710 MG
A NET inhibitor (Ki = 5.1 nM); selective for NET over DAT and SERT (Kis = 477 and 383 nM, respectively); inhibits norepinephrine uptake and inhibits amphetamine-induced increases in norepinephrine release in mouse brain (EC50s = 2.97 and 0.08 µM, respectively); reduces increases in locomotor activity induced by d-N-ethylamphetamine, methylphenidate, and cocaine, but not morphine, in mice at 32 mg/kg; reduces cataplexy in narcoleptic dogs at 0.5 mg/kg i.v.
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